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Myles Garrett and the Browns are set to visit Geno Smith and the Seahawks in a matchup of two of the NFL's top teams through seven weeks.
Cleveland is heading west to challenge Seattle at Lumen Field on Sunday.
The Browns have won two straight games and enter Week Eight fresh off a thrilling 39-38 win over the Indianapolis Colts last week.
P.J. Walker threw for 178 yards and one interception in relief of injured starting quarterback Deshaun Watson.
Walker will make the start for Cleveland this week as Watson continues to deal with a lingering shoulder issue.
The Browns are tied for second in the AFC North at 4-and-2.
The Seahawks have won four of their last five games and are coming off a 20-10 victory over the NFC West rival Arizona Cardinals in Week Seven.
Kenneth Walker the Third rushed for 105 yards in the win.
Walker is up to 450 rushing yards and six touchdowns in six games played.
Seattle is sitting second in the NFC West at 4-and-2.
The Seahawks have won two straight over Cleveland dating back to 2015.